Prediction of Extubation Failure: A Multicenter Prospective Observational Study

The First Affiliated Hospital of Chongqing Medical University

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05069441

Enrollment

2604

Registered

2021-10-06

Start date

2021-10-15

Completion date

2026-12-31

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation

Keywords

Extubation Failure

Brief summary

The investigators intend to collect several variables to predict extubation failure among patients who successfully complete a spontaneous breathing trial, and then develop a scale using simple bedside indicators to predict extubation failure.

Detailed description

Mechanically ventilated patients who successfully completed a spontaneous breathing trial and prepared for extubation are eligible to enroll in this study. The vital signs, arterial blood gas tests, cough strength, cuff leak test, use of noninvasive ventilation et al. are collected. Patients are followed up to postextubation 28-day or discharge. Extubation failure is defined as reintubatin or death within postextubation 7 days. First, we will analyze the data to predict extubation failure. Then, we will combine several easily obtained variables to develop and validate a scale to predict extubation failure. Finally, we explore the predictive power of extubation failure tested by the scale and find the cutoff value to distinguish the low, moderate and high risk of extubation failure.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Prepared for extubation through spontaneous breathing trial;Oral or nasal endotracheal intubation; be at least 18 years old

Exclusion criteria

* Extubation without a spontaneous breathing trial ;Reintubation due to secondary surgery; Tracheotomy

Design outcomes

Primary

Measure	Time frame	Description
Rate of extubation failure	From extubation to 48 hours	Extubation failure was defined as the reintubation or death

Secondary

Measure	Time frame	Description
Rate of mortality	From extubation to 28 days	Mortality in ICU and hospital
ICU stay	From extubation to 28 days	Length of ICU stay

Countries

China

Contacts

CONTACTJun Duan, Dr

duanjun412589@163.com89012017

CONTACTLinfu Bai, Dr

1023762525@qq.com89012680

PRINCIPAL_INVESTIGATORJun Duan

First Affiliated Hospital of Chongqing Medical University

Outcome results