no Conditions
Conditions
Brief summary
Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.
Detailed description
The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.
Interventions
DIETARY_SUPPLEMENTNew Zealand blackcurrant extract
Capsules taken daily or intermittent
Sponsors
University of Chichester
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * Non-smokers * Not taking any supplements * No known allergy to berries or berry products
Exclusion criteria
* Sedentary * Known high blood pressure * Smoking * On medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract | baseline, acute, one week and two weeks | The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Total peripheral resistance will be measured in (mmHg·min)/L |
| Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract | baseline, acute, one week and two weeks | The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Heart rate will be measured in beats/min. |
| Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract | baseline, acute, one week and two weeks | The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Stroke volume will be measured in mL. |
| Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract | baseline, acute, one week and two weeks | The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Cardiac output will be measured in L/min. |
| Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract | baseline, acute, one week and two weeks | The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Systolic, diastolic and mean arterial blood pressure will be measured in mmHg. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake. | baseline, acute, one week and two weeks | The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Oxygen consumption will be measured in L/min |
| Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake. | baseline, acute, one week and two weeks | The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Carbon dioxide production will be measured in L/min. |
| Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake. | baseline, acute, one week and two weeks | The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Respiratory exchange ratio is unitless and calculated from the ratio of carbon dioxide production and oxygen consumption. |
| Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake. | baseline, acute, one week and two weeks | The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Carbohydrate oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min. |
| Changes in fat oxidation from baseline with acute intake, one week and two weeks intake. | baseline, acute, one week and two weeks | The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Fat oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min. |
Countries
United Kingdom
Outcome results
None listed