Parkinson Disease
Conditions
Keywords
Parkinson's disease; Transcranial magnetic stimulation; Motor cortex; Corticomotor inhibition; Balance performance
Brief summary
Postural instability is one of the motor features of Parkinson's disease (PD). Most patients will develop balance dysfunction, and they may get worse with disease progression. According to previous studies, people with PD had abnormal changes in corticomotor excitability, especially disinhibition in the primary motor cortex (M1). Some evidence had shown that the cortical function in the M1 is crucial for the pathophysiology of the underlying motor symptoms in PD. Furthermore, neurostimulation over the M1 could modulate the corticomotor excitability in individuals with PD, and then improve their motor and also balance performance. However, whether the impaired corticomotor inhibition relates to balance dysfunction in people with PD is still unknown. In this study, the purpose is to investigate the possible relationship between corticomotor inhibition and balance performance in individuals with PD. However, the postural position during TMS measurement may affect the corticomotor excitability. To further establish the above-mentioned relationship, the secondary purpose is to explore and confirm whether the postural position will influence the correlation.
Interventions
None listed
Sponsors
National Yang Ming Chiao Tung University
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* the Hoehn and Yahr stage between 1 and 3 * age 40 to 80 years * a stable treatment of anti-PD medications
Exclusion criteria
* any contraindications of TMS * any injury histories or disorders affecting balance * any neurosurgery experience * neurologic conditions other than PD * the Mini-mental State Examination (MMSE) score \< 24
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intracortical inhibition | 20 minutes | Short-interval intracortical inhibition assessed by transcranial magnetic stimulation |
| Corticospinal inhibition | 20 minutes | Cortical silent period assessed by transcranial magnetic stimulation |
| Static balance | 3 minutes | Sharpened Romberg test |
| Dynamic balance | 5 minutes | Functional reach test |
| Functional balance | 15 minutes | Mini-Balance Evaluation Systems Test |
Countries
Taiwan
Contacts
Primary ContactYea-Ru Yang, PhD
Outcome results
None listed