Improving the Accuracy of Revised Cardiac Risk Index With HbA1C:Hemoglobin Ratio (HH Ratio)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05066386

Enrollment

20099

Registered

2021-10-04

Start date

2013-01-01

Completion date

2021-08-01

Last updated

2021-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Medicine, Risk Stratification

Keywords

HbA1C: Hemoglobin ratio (HH ratio), Risk model, RCRI

Brief summary

Retrospective observational study on the effects of altering components of RCRI to improve the predictive capacity.

Detailed description

The current Lee's Revised cardiac risk index (RCRI) was created in 1999. Validation studies have found RCRI to be only moderately discriminant. The Diabetes Mellitus on insulin component of the score does not accurately reflect the severity of the disease. A previously studied HbA1C:Hemoglobin ratio shows an improved association with outcomes than individual components alone and could be potentially used as a new marker for severity of the disease. A retrospective cohort study was performed in consecutive diabetic patients undergoing non-cardiac surgery. Ethics approval was obtained. The objective of the study is to compare the predictive value of RCRI and substitution of the DM on insulin component with HH ratio for 30- and 90-day mortality, and postoperative acute myocardial injury(AMI) and acute kidney injury(AKI).

Interventions

OTHERModified RCRI risk stratification

The objective of the study is to compare the predictive value of RCRI and substitution of the DM on insulin component with HH ratio for 30- and 90-day mortality, and postoperative acute myocardial injury(AMI) and acute kidney injury(AKI).

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Above 18 years old * Past medical history of Diabetes Mellitus or preoperative HbA1C \> 6.5% (within 3 months of surgery) * Had HbA1C done within 3 months prior to date of surgery * Undergoing non cardiac surgery * Emergency and elective surgery EXCLUSION: * If patient is below 18 years old * no History of DM * No HbA1C done within 3 months prior to date of surgery

Design outcomes

Primary

Measure	Time frame	Description
Mortality	90 days	To compare the predictive value of RCRI and substitution of the DM on insulin component with HH ratio for 30- and 90-day mortality

Secondary

Measure	Time frame	Description
Morbidity	7 days	To compare the predictive value of RCRI and substitution of the DM on insulin component with HH ratio for postoperative acute myocardial injury(AMI) and acute kidney injury(AKI).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026