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Speech Treatment for Minimally Verbal Children With ASD and CAS

Speech Treatment for Minimally Verbal Children With ASD and CAS

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05066178
Acronym
TxMVASD+CAS
Enrollment
20
Registered
2021-10-04
Start date
2024-05-01
Completion date
2030-11-30
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorder, Developmental Verbal Dyspraxia

Keywords

childhood apraxia of speech, autism, motor speech disorder, speech development

Brief summary

Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning. This study tests whether CAS-specific treatment, appropriately modified for minimally verbal children with autism, improves their speech.

Detailed description

Although one in four children with autism remain minimally verbal past age five, not all the factors that limit spoken language in these minimally verbal children are known. One powerful contributor may be a motor speech disorder, Childhood Apraxia of Speech (CAS). CAS is an impairment in the ability to plan and sequence for speech, which makes speech inconsistent and imprecise. This project proposes to investigate whether CAS makes the speech of minimally verbal children with autism unintelligible, and then to test whether treating the CAS improves children's speech. First, a cohort of 20 minimally verbal children with both autism and CAS is identified. The prediction is that the more severe the CAS, the more inconsistent and imprecise a child's speech, and therefore the lower their intelligibility will be. Then, a set of mono- and bisyllabic words is selected that contain the disordered movements that each child shows and use those in treatment. Treatment will take the form of 15 one-hour sessions where speech practice is embedded in a naturalistic, play-based milieu that is centered on each child's own developmental level. It will involve principles of motor learning (intensive practice of a few words, sometimes all in a row and sometimes mixed up). Different types of cues (touch cues, simultaneous production, etc.) will also be employed to help children say their words correctly, fading back these supports as the child's speech improves. Both of these techniques have been shown to be effective for treating CAS. Our outcome measures will include both (1) "by-ear" assessments of intelligibility and (2) acoustic and kinematic measurements of children's speech after 15 treatment sessions. The findings will inform clinical practice for minimally verbal children with autism and may lead to the development of novel interventions for this severely affected population.

Interventions

BEHAVIORALCAS Treatment for Minimally Verbal Children with Autism

Treatment involves principles of motor learning embedded in a naturalistic developmental milieu

Sponsors

MGH Institute of Health Professions
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Masking description

Outcome assessor will be blinded to participant session

Intervention model description

Multiple-baseline single-case design

Eligibility

Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
No

Inclusion criteria

* Meets criteria for Autism Spectrum Disorder * Able to correctly repeat at least 2 syllables * Meets criteria for Childhood Apraxia of Speech * Lives in an environment where child is exposed to English at least 50% of the time

Exclusion criteria

* Poorly controlled seizures * Factors such as blindness or deafness that contribute to minimally verbal status * Lives in an environment where English is not spoken at least 50% of the time * Child experiences behavioral challenges that preclude participation in the study

Design outcomes

Primary

MeasureTime frameDescription
Attempts Correct5 weeksNumber or percent of target items that were produced correctly
Phonemes Correct5 weeksNumber or percent of phonemes (vowels, consonants) in the target items that were produced correctly

Secondary

MeasureTime frameDescription
Lip aperture movement variability5 weeksAmount of variability in lip opening area during production of multiple attempts at the same target
Phoneme distinctiveness5 weeksAcoustic distinctiveness of different phonemes

Countries

United States

Contacts

CONTACTKaren V Chenausky, Ph.D.
kvchenausky@mghihp.edu617-726-2405
CONTACTMichael Moody
mjmoody@partners.org617-643-4658

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 31, 2026