Parkinson Progression Marker Initiative Online (PPMI Online)

Parkinson's Progression Markers Initiative Online Study (PPMI Online)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05065060

Enrollment

500000

Registered

2021-10-01

Start date

2021-07-28

Completion date

2041-12-01

Last updated

2026-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Keywords

Parkinson, Neurodegenerative Disorder, Prodromal, At Risk, Participant Reported Outcomes

Brief summary

Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk and predictive factors for PD. PPMI Online is part of the broader Parkinson Progression Marker Initiative aimed at identifying markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

Detailed description

PPMI is a broad program that is expanding the goals of the original PPMI study, and will include this PPMI Online protocol, as well the PPMI Clinical \[NCT04477785\], PPMI Remote, PPMI Digital protocols (with external regulatory oversight). All participants in PPMI may be asked to participate in one or all of these protocols and their enrollment in these studies may occur in varying order. PPMI participants may also be asked to participate in additional PPMI companion studies (as they are developed), which may only involve a subset of PPMI participants based on their cohort designation

Interventions

OTHERObservation

Observation

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Parkinson Disease (PD) Participants: * Male or female age 18 years or older. * Has received a diagnosis of Parkinson's disease Participants without PD: * Male or female age 18 years or older. * Has not received a diagnosis of Parkinson's disease

Design outcomes

Primary

Measure	Time frame	Description
Unified Parkinson's Disease Rating Scale Ib & II	Baseline to 240 months	Evaluates self-reported motor and nonmotor Parkinson's disease symptoms

Countries

United States

Contacts

CONTACTUniversity of California, San Francisco

info@ppmionline.org877-525-7764

PRINCIPAL_INVESTIGATORCaroline Tanner, MD, PhD

University of California, San Francisco

PRINCIPAL_INVESTIGATORKenneth L Marek, MD

Institute for Neurodegenerative Disorders

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 9, 2026