Remineralization
Conditions
Brief summary
The aim of the present study is to evaluate the efficiency of Self-assembling Peptide P11-4, Tricalcium Phosphate Fluoride Varnish, 5% F- and 5% fluoride varnish in remineralization of WSLs in primary dentition among a group of Egyptian children.
Interventions
DRUGMonomeric self - assembling peptide P11-4
Monomeric self - assembling peptide P11-4 ( Curodont Repair ) is a remineralizing agent applied on tooth surface after treating it with 3% sodium hypochlorite for 20 seconds then etching it with 37% phosphoric acid for 20 seconds followed by rinsing then dryness.
DRUGTricalcium phosphate fluoride varnish, 5% F-
Tricalcium phosphate fluoride varnish, 5% F- ( Clinpro White Varnish ) is a remineralizing agent applied on tooth surface after mixing it with a brush onto the dosage guide.
fluoride varnish (5% sodium fluoride) ( Voco-profluorid ) is a remineralizing agent applied on tooth surface then area is allowed to become wet (either by gentle rinsing or natural salivary flow) to ensure setting of VOCO Profluorid Varnish.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Masking description
Double blinded ( participant and statistician )
Eligibility
Sex/Gender
ALL
Age
3 Years to 5 Years
Healthy volunteers
Yes
Inclusion criteria
* Apparently healthy cooperative children * Aging from 3-5 years old child * Both genders * Primary teeth with active WSLs on buccal or labial surfaces * Patient and parent acceptance to treatment and maintenance of good oral hygiene
Exclusion criteria
* Restored teeth * White spot lesions due to fluorosis * Teeth with hypoplasia * Lesions that require an invasive treatment * Any pathology or concomitant medication affecting salivary flow or causing dry mouth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Size of WSL ( white spot lesion ) | through study completion, an average of 8 months | Size of WSL measured by scored dental probe |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Regression of caries | through study completion, an average of 8 months | Regression of caries evaluated by International Caries Detection and Assessment System (ICDAS) II |
| Inactivation of active carious lesions | through study completion, an average of 8 months | Inactivation of active carious lesions evaluated by Lesion activity assessment (LAA-ICDAS) |
| Mineral content of WSL | through study completion, an average of 8 months | Mineral content of WSL measured by fluorescence camera VistaCam iX |
Contacts
Primary ContactYara A Abdellatif, BDS
Backup ContactRasha Hatem, PHD
Outcome results
None listed