Cardiometabolic Health, Cognition, Healthy Aging
Conditions
Keywords
Metabolome, Microbiome, Cognition, Fruit intake
Brief summary
The objectives of this study are to investigate the effect of fruit consumption on the gut microbiota and their collective fecal and plasma metabolomes, vascular and cardiometabolic functions, cognition, and motor control.
Detailed description
The Investigators findings will provide data critical to the understanding of the effects of fruit intake on the gut microbiome and the capacity of the microbiota to biotransform nutrients contained within fruits as well as the subsequent impact on circulating status of those metabolites. Concurrently, health outcomes that may be linked to these changes including cognition, motor control, vascular function and cardiometabolic health risk markers will be assessed in healthy adults.
Interventions
OTHERFruit (2 cup eq)
participants will receive 2 cup eq fruits
OTHERFruit restriction (1/2 cup eq)
participants will receive 1/2 cups eq fruits
Sponsors
San Diego State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women 30 to 70 years old
Exclusion criteria
* History of: * stroke or myocardial infarction * gastrointestinal disorders * neurological disorders (epilepsy, multiple sclerosis, Parkinson's disease, stroke, etc) * known metabolic disorders (liver, renal or clinically diagnosed diabetes) * drug treatment for lipid reduction or hypertension, * psychiatric medication use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in composition of bacterial fecal microbiome at 8 weeks | At baseline, at 8 weeks | Bacterial fecal microbiome 16S rRNA gene amplicon libraries will be sequence using the Illumina MiSeq next generation sequencing platform. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in processing speed (cognition) at 8 weeks | At baseline, at 8 weeks | using Pattern Comparison Processing Speed Test |
| Change from baseline in Vascular health at 8 weeks | At baseline, at 8 weeks | To better understand how changes in the gut microbiota through fruit consumption are linked to changes in health outcomes, we will assess endothelial function via flow-mediated vasodilation and risk factors for cardiometabolic dysfunction in fasting blood samples collected at baseline and after 8 weeks. |
Countries
United States
Outcome results
None listed