Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, Peritoneal Carcinomatosis
Conditions
Keywords
Hyperthermic Intraperitoneal Chemotherapy, Cytoreductive Surgery, Peritoneal Cancer Index, Magnetic Resonance Enterography
Brief summary
This is a prospective observational study which will recruit 90 participants over a three-year period to investigate whether adding magnetic resonance imaging and enterography to routine computed tomography study can better predict the extend of peritoneal carcinomatosis over computed tomography alone.
Detailed description
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is a new option for patients with peritoneal carcinomatosis and the effectiveness of HIPEC depends on the extend of disease. Currently, pre-operative imaging peritoneal cancer index (PCI) is used to predict the intraoperative tumor extend and completeness of cytoreduction. However, the investigators' previous study and literature review show that imaging PCI usually underestimated intraoperative PCI, resulting in subsequent Open-Close operation. The investigators hypothesize that magnetic resonance imaging (MRI) is a better predictor of the intra-operative PCI than computed tomography (CT), and MR Enterography can better represent tumor deposits in the small intestine. This study aims to test whether the addition of MRI and MR Enterography to CT study improves the prediction performance of the intraoperative PCI and completeness of optimal cytoreduction over CT alone.
Interventions
DIAGNOSTIC_TESTMRI
Magnetic resonance imaging and enterography before surgery
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with peritoneal carcinomatosis diagnosed by computed tomography * Schedule for operation at our institute
Exclusion criteria
* Age \< 20 years old * Renal function impairment or acute renal failure * Contraindications for magnetic resonance imaging * Primary tumor not origins from colorectal cancer, gastric cancer or ovarian cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Predicting intraoperative PCI scores for patients with peritoneal carcinomatosis, using MR Enterography and CT | 36 months | The Sugarbaker's Peritoneal Cancer Index scores according to the MR enterography and CT images will be calculated pre-operatively and will be compared to the standard PCI scores obtained during operation. Basically, the scoring system divides the abdominopelvic cavity into 13 separate regions, and each region is scored 0-3 points as follows: 0 point, the absence of tumor; 1 point, tumors \< 0.5 cm in diameter; 2 points, tumors 0.5-5 cm in diameter; 3 points, tumors \> 5 cm in diameter. |
Countries
Taiwan
Contacts
Primary ContactChia-Ni Lin, MA
Backup ContactLi-Wen Lee, MD, PhD
Outcome results
None listed