Preterm Birth
Conditions
Brief summary
Research Objectives: 1. Establish a prediction and scoring system for twin premature birth. 2. To investigate the curative effect of 200mg,400mg and 600mg of vaginal progesterone in the prevention of twin premature birth. 3. To investigate the effect of stress cervical ligation in preventing premature delivery of twins. 4. The optimal dose of atosiban for the treatment of twin premature birth. 5. The influence of delivery mode on twin premature infants under 32 weeks.
Detailed description
Research Objectives: 1. Establish a prediction and scoring system for twin premature birth. 2. To investigate the curative effect of 200mg,400mg and 600mg of vaginal progesterone in the prevention of twin premature birth. 3. To investigate the effect of stress cervical ligation in preventing premature delivery of twins. 4. The optimal dose of atosiban for the treatment of twin premature birth. 5. The influence of delivery mode on twin premature infants under 32 weeks. It has now entered the second phase: clinical data collection
Interventions
DRUGProgesterone
The delivery outcomes of the three groups were compared, including the rate of premature delivery (\<37 weeks of gestation), the rate of early premature delivery (\<32 weeks of gestation), and the need for anti-tocolysis treatment. Rates of premature rupture of membranes (\<37 weeks), neonatal perinatal mortality and morbidity.
Sponsors
Caixia Liu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Masking description
The participants and the treating physicians were not informed of the grouping
Intervention model description
Prospective cohort study
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
twins with cervical length ≤ 25 mm by vaginal ultrasound at 14-32 weeks no contractions, abdominal pain and vaginal bleeding No complicated twin complications occurred during pregnancy
Exclusion criteria
Patients undergoing selective cervical ligation before 14 weeks of gestation history of liver problems or cholestasis during pregnancy Abnormal liver enzymes Abnormal renal function Local allergy to trace natural progesterone Recurrent vaginal bleeding Recurrent vaginal infection Ultrasound diagnosis of fetal abnormality Intrauterine treatment for fetal abnormalities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neonatal prognosis | one week | Preterm birth rate (\<37 weeks of gestation), early preterm birth rate (\<32 weeks of gestation), need to receive anti-tocolytic treatment; Rates of premature rupture of membranes (\<37 weeks), neonatal perinatal mortality and morbidity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gestational age and prolongation of gestational age at delivery | one year | Gestational age at which symptoms of preterm birth occur and gestational age at delivery after treatment |
Countries
China
Contacts
Primary ContactLiu caixia, Dr
Outcome results
None listed