Liver Cirrhosis
Conditions
Brief summary
The study will compare two forms of advice regarding physical activity for patients hospitalized with cirrhosis that are preparing for leaving the hospital. One arm consists of current standard of care: simple oral advice on exercise. One arm instead gives patients a structured but simple paper template on physical activity.
Interventions
BEHAVIORALStandard of Care advice on physical activity
Oral advice on exercise from a physician.
BEHAVIORALStructured advice on physical activity
A leaflet with instructions and images on different forms of physical activities as well as clear recommendations on when to perform these.
Sponsors
Karolinska Institutet
Karolinska University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Liver cirrhosis diagnosed with previous clinical assessment and radiology (de-formed liver, noduli, varices, collaterals, splenomegaly \>12 cm) or with biopsy (fibrosis grade 4). ICD-code K70.3, K74.6. * MELD \< 25 * Understanding the Swedish language. * Signed informed consent.
Exclusion criteria
* Performance status ≥3. * Severe pain which prevents the patient to perform the physical activities, as judged by the attending physician at time of discharge. * Previously liver transplanted * Unlikely to be compliant to follow-up (living in other parts of Sweden), as judged by the attending physician at time of discharge.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in quality of life summary score, as measured with the CLDQ tool | 3 months | Change in quality of life, as measured with the CLDQ tool (gives a summary score between 1-7, a higher score suggests a better quality of life). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frailty | 3 months | Frailty as measured with the Liver Frailty Index. |
| MELD | 3 months | Model of End-stage Liver Disease score (range 6-40, a higher score indicates a worse prognosis) |
| Mortality | 3 months | Overall mortality |
Countries
Sweden
Contacts
Primary ContactHannes Hagström, MD PhD
Backup ContactAndrea Lindfors, MD
Outcome results
None listed