Gastric Cancer, Metastasis
Conditions
Keywords
Gastric Cancer, Metastasis
Brief summary
The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.
Detailed description
Gastric cancer is the fourth most common cancer in Vietnam with high mortality rate. Metastasis is the leading cause of death in gastric cancer patients, with median overall survival of less than 1 year. Currently, there is no effective treatment because the molecular mechanism of metastasis remains unclear. The aim of this study is to use advanced NGS technologies to dissect the genomic changes (genetic, epigenetic and transcriptional changes) of the primary tumor and associated metastatic sites of the same patients. With that, the investigators can reconstruct the clonal evolution from primary tumor to metastasis, identify key pathways governing metastasis development that can be targeted for future therapeutic development.
Interventions
None listed
Sponsors
University Medical Center Ho Chi Minh City (UMC)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male or Female patients aged 18 years and older 2. Histologically proven primary gastric adenocarcinoma and clinical evidence of metastasis (N1-3M1) 3. Biopsies can be taken at multiple sites 4. No known other concomitant cancer diagnosis 5. Signed informed consent
Exclusion criteria
1. Gastric adnocarcinoma cannot be confirmed primary 2. Unable to undergo biopsy or surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic and epigenetic changes of the tumor | 3 months after surgery | Ultra-deep NGS of the primary tumor and associated metastatic sites from the same patients to identify mechanism governing metastasis development |
Countries
Vietnam
Contacts
Primary ContactLong Duy Vo, MD, PhD
Outcome results
None listed