Arthroplasty Complications, Prosthetic Infection, Prosthetic Joint Infection
Conditions
Brief summary
A bacterial infection of an artificial joint is a serious complication that often requires additional surgery to exchange the arthroplasty. It is also difficult to recognize an infected joint, as the symptoms caused by the infection are very similar to those of other problems with arthroplasties, such as loosening of the implant. To improve the ability to diagnose prosthetic joint infections, this study compares the levels of calprotectin, a specific inflammatory protein, in the joint fluid of infected joints and joints with other complications. The underlying hypothesis is that the level of calprotectin in infected joints is significantly higher, thus facilitating the diagnosis of prosthetic joint infection.
Interventions
DIAGNOSTIC_TESTCalprotectin Lateral Flow Test
Semiquantitative point of care photometric assay for the calprotectin level in joint fluid aspirate
Sponsors
Technical University of Munich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* scheduled arthroplasty exchange for any of the following reasons: * infection * loosening * instability * malalignment * periprosthetic fracture
Exclusion criteria
* acute prosthetic joint infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of synovial fluid calprotectin | Intraoperatively | The level of synovial fluid calprotectin measured in joint fluid aspirate as a diagnostic test for prosthetic joint infection. The accuracy is calculated by comparing its results with the International Consensus Meeting (ICM) on prosthetic joint infection criteria of 2018. |
Countries
Germany
Contacts
Primary ContactChristian Suren, M.D.
Outcome results
None listed