Colorectal Cancer, Genetics of
Conditions
Keywords
inflammatory bowel disease
Brief summary
Chronic inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC) in historical cohorts. The pathways of oncogenesis of these CRCs, which are very different clinically from de novo CRCs, are currently unknown. The aim of our work is to identify specific molecular signatures of CRC occurring in the setting of IBD.
Interventions
GENETICtranscriptomic analysis
transcriptomic analysis on preserved tumor tissue
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Inclusion criteria
* Person 18 years of age or older * Person with colorectal cancer in the context of IBD * Person who has received complete information on the organization of the research and who has signed an informed consent * Person affiliated to a social security plan or beneficiary of such a plan.
Exclusion criteria
* Person referred to in articles L. 1121-5, L. 1121-7 and L1121-8 of the public health code: * Pregnant woman, parturient or nursing mother * Minor (not emancipated) * Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice) * Person of legal age who is unable to express his or her consent * Person deprived of liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1 and L. 3213-1.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IBD associated CRC oncogenesis | 1 year | Percentage of gene expression variation in CRC tumor tissue samples in the following groups patients with CRC and IBD |
Outcome results
None listed