Delirium
Conditions
Brief summary
The current project aims to measure biomarkers in the cerebrospinalfluid (CSF) and serum samples from patients with delirium. We hope to uncover new insights into the pathophysiology of delirium and explore its link to dementia.
Detailed description
Delirium is a common and serious complication to acute illness, and is characterized by acute disturbances in attention, awareness, and cognition. Dementia is a major risk factor of delirium, and delirium increases the risk of dementia progression and development. As the conditions share both clinical and epidemiological features, some researchers suggest that also pathophysiological links are shared. Understanding delirium pathophysiology, which is poorly understood, may thus help elucidate early molecular mechanisms in dementia. This study aims to to increase our understanding of the pathophysiology of delirium and molecular links between delirium and dementia, by exploring cerebrospinal fluid (CSF) biomarkers.
Interventions
PROCEDUREHip fracture surgery
Hip fracture surgery
Sponsors
Oslo University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with acute hip fracture
Exclusion criteria
* Moribund patients. * Lack of consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Delirium | Daily during hospital stay (pre-/and postoperatively) until 5 days after surgery (or discharge) | Pre- and postoperative delirium |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Dementia | Cognitive changes the first 48 months after inclusion | Incident dementia |
Countries
Norway
Contacts
Primary ContactLeiv O Watne, PhD
Outcome results
None listed