Osteopenia, Osteoporosis, Postmenopausal Osteoporosis, Sarcopenia
Conditions
Keywords
aging, bone, muscle, exercise
Brief summary
The aim of the 2 month randomized controlled trial is to investigate the feasibility of a novel progressive muscle resistance exercise in individuals with low bone mass.
Detailed description
In 2008, medical cost of osteoporosis and osteoporosis-related fractures was estimated to be $22 billion. This is further expected to rise because of an increase of 20% in population with osteoporosis, amounting to 12 million adults over the age of 50 years, by 2020, out of which 80% will be postmenopausal women. Unfortunately, benefits due to pharmacological interventions have plateaued. Consequently, there is a critical need to identify complementary therapies to enhance the treatment of low bone mass in older adults. The aim of this study is to examine the feasibility of novel progressive muscle resistance exercise in postmenopausal women with low bone mass. Muscle will be assessed via imaging techniques and isokinetic dynamometer. Physical activity will be assessed via activity monitors. Blood will be collected to assess bone and muscle biomarkers. Balance will be assessed via clinical and biomechanical tests. Testing will be performed at 4 time points: baseline, 1 month, 3 month, and 6 months except imaging which will be done at the baseline and 6 months. The findings from this study will help us to understand the feasibility of resistive muscle exercise program in postmenopausal women with low bone mass.
Interventions
OTHERExercise training
Progressive muscle resistive exercise will be performed by the experimental group only. Control group will maintain their normal level of daily activity.
Sponsors
University of Alabama at Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcomes assessor will be blinded to the group assignment.
Intervention model description
Individuals will be randomly assigned to exercise or no exercise group.
Eligibility
Sex/Gender
FEMALE
Age
55 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* independent ambulatory * diagnosed with low bone mass
Exclusion criteria
* uncontrolled hypertension * secondary osteoporosis * fragility fracture, * clinical or laboratory evidence of hepatic * renal disease, * uncontrolled disorders of the parathyroid * thyroid glands, * a history of cancer in the past 5 years, * any structured resistance training within the previous year, and * past therapy with any drug for osteoporosis, * any current therapy for osteoporosis except zoledronic acid, * inability to walk independently or * any other medical conditions which could restrict the potential participants from full participation as decided by their physician.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone biomarker | baseline | bone formation and resorption marker |
Contacts
PRINCIPAL_INVESTIGATORHARSHVARDHAN SINGH, PT, PhD
University of Alabama at Birmingham
Outcome results
None listed