Exploring the Role of Almonds in Enhancing Immune Strength

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05059639

Enrollment

Registered

2021-09-28

Start date

2021-11-15

Completion date

2024-11-15

Last updated

2025-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune Health

Keywords

Almonds

Brief summary

The COVID-19 pandemic highlights the importance of good nutritional status for immune strength and for reducing comorbidities that increase morbidity and mortality of infections. The major aim of this study is test if almond consumption can improve immune function.

Detailed description

Investigators will conduct an 8-week parallel-arm trial of 48 overweight/non-obese (BMI=24-30) adult (aged 40-65 years) men (n=24) and women (n=24) who will be randomly assigned to consume daily isoenergetic portions of almonds or a common snack (pretzels).

Interventions

OTHERAlmond

Consume 2 ounces of almond daily for 8 weeks

OTHERPretzel

Consume comparative amount of pretzel daily for 8 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Intervention model description

forty-eight overweight/non-obese (BMI=24-30) adult (ages 40-65 years) men (n=24) and women (n=24) will be recruited to participate. A randomized, parallel-arm design will be utilized.

Eligibility

Sex/Gender

ALL

Age

40 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Healthy male and female subjects aged 40-65 y * Body mass index (BMI) 24-30 kg/m.2

Exclusion criteria

* Not willing to stop taking multivitamins, and supplements (with the exception of vitamin D and calcium), for 30 days prior to or during study participation, if currently taking these. * Almond allergies * Alcohol consumption \>2 drinks per day. * Smoking or using nicotine containing products in the last 6 months.

Design outcomes

Primary

Measure	Time frame	Description
change in Natural Killer Function	Baseline, after 8 weeks	The ability of peripheral blood mononuclear cells to bind and kill leukemia cells will be measured at baseline and at week-8 of the diet intervention using flowcytometry by assessing the concentration of natural killer cells.

Secondary

Measure	Time frame	Description
change in Cytokines	Baseline, after 8 weeks	Peripheral blood will be analyzed at baseline and week-8 of diet intervention for cytokines including IL1, IL-6 and TNF alpha concentrations.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026