Inflammation Function, Postoperative Cognitive Function, Postoperative Pain, Postoperative Sleep Quality, Sex Differences
Conditions
Brief summary
Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. And sleep disruption also remains a challenging problem in surgical settings. Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patient's physical condition. The aim of the study was to investigate the effect of sex differences on postoperative pain, inflammation, sleep quality and cognitive function among patients who have undergone video-assisted thoracoscopic surgery under general anesthesia.
Interventions
OTHERVideo-Assisted Thoracoscopic Surgery
patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia
Sponsors
Shengjing Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* 18-75 years old * ASA I-III * under general anesthesia
Exclusion criteria
* patients with central nervous system and mental diseases; * patients with preoperative sleep disturbances; * patients with a history of sedative, analgesic, or antidepression drug use; * patients with sleep apnea or moderate and severe obstructive sleep apneahypopnea syndrome;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neuropsychological test | Neuropsychological tests were carried out the day before and 5 to 7 days after surgery. The second neuropsychological test time for control subjects was 6 to 9 d | The neuropsychological test battery included the tests used to evaluate patients for delayed neurocognitive recovery in the International Study of Post-Operative Cognitive Dysfunction: (1) word learning: visual verbal learning test based on the Rey's auditory recall of words; (2) word recall: the number or words recalled from visual verbal learning trials after a 20-min delay; (3) cognitive flexibility: including trail making test A and B; (4) distractibility: Stroop color word interference test; and (5) working memory: letter-digit coding. If a patient exhibited delirium at a testing time, neuropsychological evaluation was postponed 3 days. |
| preoperative inflammation function | three days before surgery | evaluate systemic immune inflammation index (SII) before operation |
| postoperative inflammation function | three days after surgery | evaluate systemic immune inflammation index (SII) after operation |
| sleep quality of one night before surgery | one night before surgery | use the athens insomnia scale to evaluate subjective sleep quality (0 to 24 points, with ≥ 6 points indicating a diagnosis of insomnia) |
| sleep quality of first night after surgery | first night after surgery | use the athens insomnia scale to evaluate subjective sleep quality (0 to 24 points, with ≥ 6 points indicating a diagnosis of insomnia) |
| sleep quality of third night after surgery | third night after surgery | use the athens insomnia scale to evaluate subjective sleep quality (0 to 24 points, with ≥ 6 points indicating a diagnosis of insomnia) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative adverse effects | 24 hours after surgery | evaluate postoperative adverse effect 24 hours after surgery |
| visual analog scale(VAS) score after surgery | 24 hours after surgery | evaluate VAS (0-10 points)score 24 hours after surgery |
Countries
China
Contacts
Primary Contactjunchao zhu
Outcome results
None listed