Monkeypox Virus Infection
Conditions
Keywords
epidemiology, outbreak investigation, anthropology,, animal reservoir, zoonotic disease, field diagnosis
Brief summary
This multidisciplinary project aim to understand the epidemiology of the monkeypox in Central African Republic through the identification of the animal reservoir, the clinical and epidemiological description of the human outbreak, through an ethnological approach around risk factors of the disease and through an ecological approach of the ecological context of emergence, and the improvement of biological diagnosis.
Detailed description
This project is composed by monkyepox disease outbreak investigation in the CAR following national surveillance framework.
Interventions
OTHERblood samples
5 mL
OTHERScabs and pus samples
if available
Sponsors
Institut Pasteur de Bangui
Institut Pasteur
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Human population in villages affected by monkeypox epidemics: patients who developed monkeypox and their contacts * Health care personnel (paramedics, nurses, doctors) who work or have worked in affected villages * Traditional healers, diviners * Members of villages affected by past monkeypox epidemics
Exclusion criteria
* area not accessible to investigation * refusal to participate * inability to obtain consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of monkeypox cases occuring following interhuman exposures | 36 months | through a quantitative case-control study with an odds ratio of \>3 for an exposure factor for human-to-human transmission. |
| Proportion of monkeypox cases occuring following zoonotic exposures | 36 months | through a quantitative case-control study with an odds ratio of \>3 for an exposure factor for zoonotic transmission. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identification and interpretation of genomic viral mutations from the viral sequences isolated from humans and animals in CAR for Phylogenetic and phylogeographic study of the monkeypox virus | 36 months | identification and interpretation of mutations, search for the common ancestor. |
| Measurement of the Effective reproduction rate R in CAR according to the level of immunity (smallpox vaccine immunity or orthopoxvirus-related post disease immunity). | 36 months | measurement of the level of population natural immunity and post vaccinal immunity to determine the Effective reproduction rate R and changes in R between 2000-2020 according to the evolution of immunity (smallpox vaccine immunity or orthopoxvirus-related post disease immunity). |
| Identification of the characteristics associated with the environments in which human cases of monkeypox virus infection have occurred | 36 months | ecosystems and their recent modifications, land use, associated climatic/meteorological elements in the tropical zone (CAR, Northern DRC...). |
| Comparison of genetic proximities between different viral strains isolated in humans and animals in CAR and neighboring countries since 1980. | 36 months | Comparison of genetic proximities |
| measurement of the sensitivity and the specificity of the existing diagnostic tests and those developed within the framework of the project | 36 months | sensitivity and specificity of the existing diagnostic tests and those developed within the framework of the project, as well as the reproducibility of measurements in relation to reference tests. |
Countries
Central African Republic
Outcome results
None listed