Ketone Plasma Kinetics After Oral Intake of Different Ketogenic Formulae

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05058157

Enrollment

Registered

2021-09-27

Start date

2023-08-21

Completion date

2024-12-31

Last updated

2023-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Men and Women

Brief summary

This research project aims at evaluating the effect of various ketone precursors and their formulations on blood ketone level after oral intake. Evaluation of the GI tolerability of the various formula will be also evaluated.

Interventions

DIETARY_SUPPLEMENTdifferent ketogenic formulae

The research product may be in a form of powder to reconstitute or in a ready-to-drink format.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Each testing cycle design will be either a complete or partial cross-over.

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy men and women, based on the screening visit and medical history, * BMI in the normal and overweight range 18.5 ≤ BMI ≤ 27; * Able to understand and sign informed consent form.

Exclusion criteria

* Any medication possibly impacting the postprandial glucose and insulin response (based on anamnesis), * Any medication impacting dietary fat absorption and metabolism, * Pregnancy (on anamnesis) and/or lactation, * Known food allergy and food intolerance, * Individuals undergoing either dietary or exercise mediated weight loss program prescribed by a health care professional, * Individuals under ketogenic diets, or taking regular ketones products, * Alcohol intake higher than 2 servings per day. A serving is 0.4 dl of strong alcohols, 1 dl of red or white wine, or 3 dl of bier, * Having given blood within the last month, or willing to make a blood donation until one month following the end of the study, * Family or hierarchical relationships with Clinical Innovation Lab at Nestlé Research, Lausanne, Switzerland, * Volunteer who cannot be expected to comply with the protocol, * Smokers unable to stop for the day of the visit.

Design outcomes

Primary

Measure	Time frame	Description
Ketone Plasma Kinetics After Oral Intake of Different Ketogenic Formulae	0 (baseline) to 4 hours after products consumption	Incremental area under the curve of total blood ketones

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026