Acute Myeloid Leukemia
Conditions
Keywords
AML, leukemia,, myeloid sarcoma, extramedullary disease
Brief summary
Patients with extramedullary leukemia were identified over 10 years (January 2003 to September 2019). Clinicopathological,genetic-molecular features were identified and survival outcomes were studied and analyzed.
Detailed description
We retrospectively collected patients demographics ,including clinicopathological and genetic-molecular parameters in patients with extramedullary leukemia between January 2003 till September 2019 from King Hussein cancer center(KHCC) electronic medical records. All potential prognostic factors were identified and compared with worldwide data published previously. Treatment and survival outcomes were studies and analyzed. Primary endpoint : Overall survival (OS). Secondary endpoint : * Progression Free Survival (PFS). * incidence of extramedullary leukemia.
Interventions
chart review, analysis and reporting outcomes
Sponsors
King Hussein Cancer Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult subjects aged ≥18 year and up to 75 years * Male and females. * Initially diagnosed and treated with extramedullary leukemia at KHCC and followed till last encounter. * Patients, who underwent an allogeneic stem cell transplant. * Period January 2003-September 2019
Exclusion criteria
* Pediatric patients \<18 year of age * Patients, who lost their follow up within study period.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival (OS), | 4 year, year 4 | To calculate the median and estimated 4-year overall survival |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Progression-Free Survival | 4 year, year 4 | To calculate the median and estimated 4-year PFS |
Countries
Jordan
Outcome results
None listed