Anorexia Nervosa, Bulimia Nervosa
Conditions
Brief summary
The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39. Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC. Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC. Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later. Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.
Interventions
None listed
Sponsors
University of California, San Diego
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
Eating Disorder Group: * Between the ages of 18 and 39 years old * Meet DSM-V criteria for AN-R, AN-BP, or BN Healthy Control Group: * Between the ages of 18 and 39 years old * Have maintained 85% to 120% ideal body weight since menarche
Exclusion criteria
All Groups: * Psychotic illness/other mental illness requiring hospitalization * Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures. * Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight * Neurological disorder, neurodevelopmental disorder, or history of head injury with \>30 min loss of consciousness * Any contraindication to undergoing an MRI * Primary obsessive compulsive disorder or primary major depressive disorder Additional
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BOLD response | 1 Year | Brain activity associated with 'liking', 'wanting', and learning |
| Reward and Punishment Learning | 1 Year | Task reinforcement learning rate in reward and punishment trials |
| Connectome-based predictive modeling (CPM) | 1 Year | Functional connectivity maps from task-based fMRI data and clinical data |
Countries
United States
Contacts
CONTACTChristina Wierenga
Outcome results
None listed