Infertility
Conditions
Keywords
infertility, cycle
Brief summary
With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring through assisted reproductive technology. However, a growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. The purpose of this study is to investigate the stress faced by participants undergoing ART with different cycles and to further investigate its impact on pregnancy outcomes.
Detailed description
With the rapid social and economic development in recent years, the incidence of infertility has increased significantly due to environmental pollution, poor lifestyle habits and increasing stress in various areas. According to global statistics, one in six married couples suffers from infertility. With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring. In clinical practice, however, a significant proportion of patients undergoing ART have low embryo implantation and pregnancy rates and experience recurrent implantation failure (RIF). A growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. This effect is more pronounced in patients with multiple failed transfers. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with different cycles to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
Interventions
OTHERcycles
Patients are grouped according to the number of IVF/ICSI cycles.
Sponsors
Women's Hospital School Of Medicine Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Female partners' \>18\< 40 years * Patients undergoing assisted reproductive technology
Exclusion criteria
* Female partners with polycystic ovary * Female partners with insufficiency or premature ovarian failure * Female partners with endometriosis * Female partners with abnormal profile of thyroid hormones * Chromosomal abnormalities of either spouse * Mental disorder of either spouse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implantation rate | 6 months | Implantation rate is defined as number of sacs per embryo transferred. |
| clinical pregnancy rate | 6 months | presence of at least one gestational sac on ultrasound of 6 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fertilization rate | 6 months | No. of fertilized oocyte divided by No. of inseminated cumulus-oocyte complexes (COCs) |
| cleavage rate | 6 months | No. of cleaved embryo divided by No. of fertilized oocyte |
| Total gonadotropin use | 6 months | Total gonadotropin use of each participant |
| Ovarian hyperstimulation syndrome (OHSS) rates | 6 months | OHSS rates in both study groups |
| Number of oocytes retrieved | 6 months | — |
| Metaphase II (MII) oocytes | 6 months | the number of mature oocytes |
Countries
China
Contacts
Primary ContactYimin Zhu, Dr.
Outcome results
None listed