Obesity, Childhood, PreDiabetes
Conditions
Brief summary
The purpose of this study is to evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of glucose tolerance (normal to prediabetes or prediabetes to diabetes) in an overweight and obese pediatric cohort.
Interventions
None listed
Sponsors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
University of Michigan
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
8 Years to 22 Years
Healthy volunteers
Yes
Inclusion criteria
* Groups 1 and 2 (overweight and obese groups): * Age 8-17 years for the visits #1 and #2, individuals can be as old as 22 years for follow-up visits #3 and 4 * Overweight or obese, as defined by a BMI ≥ 85th% & \<95th% or BMI ≥ 95th%, respectively by age and sex, and for those 16 years and older, BMI ≥25 and \<30 and BMI ≥30 * For Group 2 only: previously completed visits 1-2 in 2007-2013 and formally agreed to be re-contacted for study purposes * Group 3 (Normal weight controls): * Age 8-17 years * Healthy weight, as defined by a BMI ≥ 5th percentile & \< 85th percentile, respectively by age and sex
Exclusion criteria
* Previous diagnosis of type 1 diabetes * Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin) * Verbal report of Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression of glucose tolerance | Up to 5 years | Normal glucose tolerance, prediabetes, or diabetes |
Countries
United States
Outcome results
None listed