COPD
Conditions
Keywords
Nasal High Flow, PaCO2, Tidal Volume, Washout Effect
Brief summary
Controlled randomized crossover trial in patients with chronic obstructive respiratory disease (COPD), who are treated with Nasal High Flow (NHF) therapy during wakefulness with a small amount of CO2 added to the inhaled air to keep the patients' PaCO2 stable despite the washout effect. Aim of the study is to examine respiratory rate, tidal volume and work of breathing under NHF without the CO2 washout effect.
Detailed description
In this controlled randomized crossover trial, 10 stable patients with chronic obstructive respiratory disease (COPD) are treated with Nasal High Flow (NHF) therapy during wakefulness. NHF treatment will inevitably result in increased upper airway washout and thus in a slight reduction of PaCO2 of approximately 2 mmHg. For compensation, a small amount of CO2 is added to the inhaled air during this experimental situation, which keeps the patients' PaCO2 stable. This will allow to examine the effects of NHF therapy on respiratory rate, tidal volume and work of breathing, that are not attributable to the CO2 washout effect.
Interventions
DEVICENasal High Flow (NHF)
Patients with chronic respiratory failure are treated for 1 h with NHF therapy and with individual O2 supplementation during wakefulness.
Sponsors
Institut für Pneumologie Hagen Ambrock eV
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hospitalized COPD patients GOLD (3 and 4) in stable phase after an acute exacerbation. * Written informed consent is required for participation.
Exclusion criteria
* Acute respiratory failure with clinical instability or respiratory acidosis defined by pH\<7.35 * Severe acute physical illness that does not allow the subject to participate in a clinical trial * Unable to give consent * Language, cognitive, or other impairments that may prevent independent completion of questionnaires
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Minute Ventilation | up to 1 hour | Difference in respiratory minute volume under NHF versus NHF/CO2. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Transcutaneous pCO2 | up to 1 hour | Difference in transcutaneous pCO2 under NHF versus NHF/CO2. |
| Tidal Volume | up to 1 hour | Difference in tidal volume (VT) under NHF versus NHF/CO2 |
| Respiratory Rate | up to 1 hour | Difference in respiratory rate under NHF versus NHF/CO2. |
Countries
Germany
Outcome results
None listed