Atherosclerosis, Exercise, Metformin, Pre Diabetes
Conditions
Keywords
Prediabetes, exercise, metformin, atherosclerosis
Brief summary
The aim of this study is to evaluate whether there is a change in carotid intima media thickness with the application of guide-based exercise programs in individuals with prediabetes, and to evaluate whether there is a difference between the group in which exercise programs were applied and those who received only lifestyle change and metformin.
Detailed description
The researchers think that the application of guide-based exercise programs in prediabetes patients will decrease the carotid intima-media thickness.The aim of this study is to evaluate whether there is a change in carotid intima media thickness with the application of guide-based exercise programs in individuals with prediabetes, and to evaluate whether there is a difference between the group in which exercise programs were applied and those who received only lifestyle change and metformin.
Interventions
BEHAVIORALExercise
1 hour of moderate-intensity aerobic exercise 3 days a week for 12 weeks
Sponsors
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Leading a sedentary life * Those who have sufficient motivation to participate in the exercise program (will be evaluated by a one-on-one interview by the researchers) * Have the same weight for 6 months before participating in the study (±2.5 kg) * Those diagnosed with prediabetes by oral glucose tolerance test and/or HbA1c measurement
Exclusion criteria
* Serious medical condition (for example, advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.) that would prevent the person from participating in exercise training. * Having cardiovascular disease * Being diabetic * Using metformin before participating in the study * Receiving hormone replacement therapy * Life expectancy less than 1 year * HIV positivity * Substance use * Functional dependency * Cognitive weakness * Those who have other diseases that will affect the results of the study (respiratory diseases, muscle diseases, etc.) * Those who use drugs or supplements that will affect the results of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Carotid ultrasound | 12 weeks | milimeter size of carotid intima media thickness |
Countries
Turkey (Türkiye)
Contacts
Primary ContactElif Yıldırım Ayaz, M.D.
Backup ContactEmine Şeyma Denli Yalvaç, M.D.
Outcome results
None listed