Inflammatory Response
Conditions
Keywords
resistance exercise, equal training volume, immune response
Brief summary
Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected. The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.
Interventions
Subjects in high-load trial performed 4 sets per exercise, 8 repetitions with load of 85%-8RM with 90 sec of rest between sets.
Subjects in low-load trial performed 4 sets per exercise, 15 repetitions with load of 45%-8RM with 90 sec of rest between sets.
Sponsors
National Taiwan Normal University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: 20-30 * Healthy male * Without experience of resistance training
Exclusion criteria
* No acute or chronic musculoskeletal symptoms * Smoking * Alcohol or drug abuse * Fail to conduct resistance exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in glucose | 4-hour during each study intervention | glucose in mg/dL |
| Changes in insulin | 4-hour during each study intervention | insulin in mU/L |
| Changes in TG | 4-hour during each study intervention | TG mg/dL |
| Changes in uric acid | 4-hour during each study intervention | uric acid mg/dL. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Borgs Ratings of Perceived Exertion (RPE) | 1-hour during each exercise intervention | Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion). |
| Changes in ET-1 | 4-hour during each study intervention | ET-1 in pg/mL |
| Changes in NO | 4-hour during each study intervention | NO in µmol/L |
| Changes in lactate | 4-hour during each study intervention | lactate in mmol/L |
| Heart rate (HR) | 6-hour during each study intervention | HR will be measured during each study intervention. |
| Visual Analogue Scale (VAS) of appetite | 6-hour during each study intervention | Hunger, fullness, desire to eat, and prospective food consumption will be measured via VAS ratings, based on a 100 mm long scale (0 being not at all, 100 being extremely). |
| Changes in biomarkers of appetite | 4-hour during each study intervention | Biomarkers of appetite will be measured such as ghrelin in pg/mL and PYY in pg/mL. |
| Changes in biomarkers of muscle damage | 4-hour during each study intervention | Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L. |
| Changes in complete blood count | 4-hour during each study intervention | blood cell count in count per µL |
| Changes in biomarkers of inflammation | 4-hour during each study intervention | Biomarkers of inflammation will be measured such as IL-10 in pg/mL and IL-6 in pg/mL. |
| Changes in cortisol | 4-hour during each study intervention | cortisol in ng/mL |
Countries
Taiwan
Outcome results
None listed