Cerebral Blood Flow
Conditions
Keywords
Prone Position, Acute Respiratory Distress Syndrome, Intracranial Pressure
Brief summary
Prone position (PP) is a key component to treat hypoxemia in patients with severe acute respiratory distress syndrome (ARDS). However, most studies evaluating PP effects in patients with ARDS exclude those with brain-injuries without providing any medical evidence. This prospectice observational study aimed to investigate if prone positioning leads to significant modification of cerebral perfusion in brain-injured patients with ARDS.
Interventions
TCD ultrasonography is based on the principle of the Doppler effect. According to this principle, ultrasound waves emitted from the Doppler probe are transmitted through the skull and reflected by moving red blood cells within the intracerebral vessels. The difference in the frequency between the emitted and reflected waves, referred to as the Doppler shift frequency, is directly proportional to the speed of the moving red blood cells (blood flow). Cerebral blood flow (in cm/s) of the middle cerebral artery will be measured with TCD in blood-injured ARDS patients before and one hour after prone positioning (normal ranges: 48 to 72 cm/s).
Sponsors
Fondation Ophtalmologique Adolphe de Rothschild
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Age
18 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* adult's patients suffering from brain injuries * patients neurologically monitored with TCD * patients requiring prone position for severe ARDS
Exclusion criteria
* pregnant women * patients with contrindication to prone position
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral Blood Flow | 1 hour | Cerebral Blood Flow measurement before and after prone positioning |
Countries
France
Outcome results
None listed