Thyroid Uptake Quantification on a New Generation of Gamma Camera

Quantitative Analysis of 99mTc-Pertechnetate Thyroid Uptake With a Large Field CZT Gamma Camera: Feasibility and Comparison Between SPECT/CT and Planar Acquisitions

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05049551

Acronym

QUANTHYC

Enrollment

Registered

2021-09-20

Start date

2019-10-30

Completion date

2020-09-07

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperthyroidism

Keywords

thyroid, uptake, quantification, CZT, Planar, SPECT/CT

Brief summary

The primary objective of this study is to evaluate the potential of a new large field CZT gamma camera to estimate the thyroid uptake (TU) on Single photon emission computed tomography (SPECT) and SPECT/CT images in comparison with standard planar scintigraphy. The secondary objective is to analyze the diagnostic contribution of SPECT/CT imaging.

Detailed description

Planar and SPECT/CT scintigraphy will be performed on a new generation large field CZT gamma camera and thyroid uptake (TU) value will be calculated on planar acquisition for 23 consecutive patients referred in our department for hyperthyroidism. With a quantitative approach using attenuation, scatter correction and iterative algorithm with resolution recovery we will have the possibility to calculate the TU value with SPECT or SPECT/CT acquisitions. Our primary objective will be to evaluate the potential of a new large field CZT gamma camera to estimate the thyroid uptake on SPECT (Tomography without attenuation correction) and SPECT/CT (tomography with attenuation correction) acquisitions compared with standard planar scintigraphy as a gold standard. The secondary objective will be to analyze the diagnostic contribution of SPECT/CT images. To established this study it will be necessary to introduce cross-calibration factors performed from a thyroid phantom, for planar and SPECT acquisitions, to estimate the thyroid uptake values.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Hyperthyroidism confirmed by blood test (TSH) and thyroid ultrasound

Exclusion criteria

* Pregnant women

Design outcomes

Primary

Measure	Time frame	Description
Thyroid uptake	Inclusion	Quantification of thyroid uptake

Secondary

Measure	Time frame	Description
SPECT/CT	Inclusion	Diagnostic contribution of SPECT/CT

Countries

Monaco

Outcome results