Endometrial Polyps, Endometritis, Subseptate Uterus, Tuberculous Endometritis
Conditions
Keywords
HFNO, Hysteroscopy, Sedation, Hypoxia
Brief summary
To determine whether high-flow nasal cannula oxygen can reduce the incidence of hypoxia during the procedure of sedated hysteroscopy.
Interventions
DEVICEHigh Flow Nasal Cannula oxygen (HFNO)
The AIRVO2 is set at 30L/min, FiO2 100%, and 37℃ before anesthesia induction，and then 60L/min until the end of the procedure of sedated hysteroscopy.
DEVICERegular oxygen
The patients are administered oxygen of 3L-6L/min until the end of the hysteroscopy operation.
Sponsors
RenJi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. 20 years old ≤ age ≤ 50 years old, female. 2. Undergoing hysteroscopy sedated with propofol for diagnosis or treatment. 3. Informed consent 4. BMI≤28kg/m2. 5. ASA physical status Ⅰ\ Ⅱ.
Exclusion criteria
1. Epistaxis, nasal congestion and nasal mucosal damage. 2. Confirmed brain disease (cranial trauma, tumor, stroke, cognitive dysfunction etc.). 3. Confirmed severe heart disease (heart failure, angina pectoris, myocardial infarction, arrhythmia, etc.). 4. Confirmed severe lung diseases (upper respiratory tract infection, asthma, bronchitis, COPD, bullae, pulmonary embolism, pulmonary edema, lung cancer, etc.). 5. Pregnant women. 6. Acute and chronic hepatitis or liver cirrhosis with severe abnormal liver function. 7. Acute and chronic nephritis with severe abnormal renal function or renal failure. 8. Needing oxygen inhalation for underlying diseases. 9. Emergency surgery. 10. Combined with multiple trauma. 11. Allergic to soybean
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of hypoxia | Patients will be followed for the duration of hospital stay, an expected average of 2 hours | 75%≤SpO2\<90% and \<60S |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of sub-clinical respiratory depression | Patients will be followed for the duration of hospital stay, an expected average about 2 hours | 90%≤SpO2\<95% |
Other
| Measure | Time frame | Description |
|---|---|---|
| The incidence of severe hypoxia | Patients will be followed for the duration of hospital stay, an expected average about 2 hours | SpO2 \< 75% or 75% ≤ SpO2 \<90% for \>= 60 s |
| The incidence of other adverse events | Patients will be followed for the duration of hospital stay, an expected average about 2 hours | Other adverse events recorded by tools proposed by the World Society of Intravenous Anesthesia International Sedation Task Force |
Countries
China
Contacts
Primary ContactHuang Yonglei, BA
Backup ContactLu Qi, BA
Outcome results
None listed