Aging, Brain Diseases, Cerebral Hypoxia, Cognitive Decline, Exercise, Healthy Aging, Hypoxia
Conditions
Brief summary
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.
Interventions
PROCEDUREHypoxia and/or Exercise
Hypoxia at rest versus normoxia at rest; Hypoxia during exercise versus Normoxia during exercise.
Sponsors
University Hospital, Grenoble
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
Double-blind (participant and research team) study in relation to the gas being delivered (normoxic or hypoxic mixture) during intervention.
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* 60 to 80 years of age; * Being physically inactive (less than 150 min/week of moderate to intense physical activity); * No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program; * Health coverage; * Being able to provide written fully informed consent.
Exclusion criteria
* Body-mass index \>30 kg/m2; * Smoking (\> cigarettes/day); * Alcohol use (\> 10g/day); * Mental disorder or history of mental disorder; * Beta-blockade treatment; * Inability or refusal to provide informed consent; * No health coverage * People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials; * People deprived of freedom by judicial or administrative decision; * People subject to legal protection, who cannot be included in clinical trials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Middle cerebral artery flow velocity | Before intervention; right after intervention; 2 months after intervention | Changes in middle cerebral artery flow velocity in response to hypercapnia (5% CO2) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak oxygen uptake | Before intervention; right after intervention; 2 months after intervention | Peak oxygen uptake during a cardiopulmonary exercise test |
| Flow-mediated dilation | Before intervention; right after intervention; 2 months after intervention | Flow-mediated dilation in response to ischemia-reperfusion of the brachial artery |
| Blood pressure | Before intervention; right after intervention; 2 months after intervention | 24h (systolic, diastolic and mean) blood pressure assessment |
| Sleep | Before intervention; right after intervention; 2 months after intervention | Sleep features assessed by polygraphy |
| Cognitive function | Before intervention; right after intervention; 2 months after intervention | Cognitive function assessed by the Montreal Cognitive Assessment questionnaire |
| Health-related quality of life | Before intervention; right after intervention; 2 months after intervention | Health-related quality of life assessed by the SF-36 questionnaire |
Countries
France
Contacts
CONTACTStéphane Doutreleau, MD, PhD
CONTACTSamuel Vergès, PhD
PRINCIPAL_INVESTIGATORStéphane Doutreleau, MD, PhD
CHU Grenoble Alpes, Grenoble Alpes University
Outcome results
None listed