Postoperative Blood Loss
Conditions
Brief summary
This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to incision followed by 1 gram IV infused at the time of wound closure.
Interventions
DRUGTranexamic acid
TXA to be given at time of diagnosis in the emergency department (ED) in treatment group and at time of operation for both groups
Sponsors
Ascension Health
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 1\. All adult (18 years old or older) hip fracture patients presenting with an acute hip fracture and undergoing operative fixation
Exclusion criteria
1. Polytrauma patients 2. Previous operation on the ipsilateral hip 3. Patients with coagulopathies (Factor V Leiden, Sickle Cell Anemia, Etc.) 4. Patients with \< 6-month history of thromboembolic event (DVT/PE), Stroke, Cardiac Stents, or Myocardial Infarction (MI) 5. History of seizure disorder 6. Patients on birth control 7. Pregnant Women 8. Prisoners 9. Active thromboembolic disease (DVT/PE, MI, Stroke)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Blood Transfusion | Up to two weeks | Patient receives a blood transfusion during their postoperative stay in the hospital |
| Overall Blood Loss | Up to two weeks | Calculate the difference in postoperative blood loss between groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | Up to two weeks | Overall length of hospital stay |
| Postoperative Pain | Up to two weeks | Difference in overall pain scores between groups |
| Wound complications | Up to two weeks | Acute wound complications documented after surgical intervention |
| Acute DVT/PE | Up to two weeks | Documented deep venous thrombosis or pulmonary embolism |
Countries
United States
Contacts
Primary ContactJacob Hinkley, DO, MS
Backup ContactJacob Lytle, DO
Outcome results
None listed