Cardiomyopathies, Cirrhosis, Liver, Portal Hypertension
Conditions
Brief summary
The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).
Interventions
PROCEDURETransjugular intrahepatic portosystemic shunt implantation
Transjugular intrahepatic portosystemic shunt is an artificial channel within the liver that establishes communication between the inflow portal vein and the outflow hepatic vein. It is used to treat portal hypertension (e.g., in liver cirrhosis)
DIAGNOSTIC_TESTMagnetic resonance imaging
Multiparametric cardiac and hepatic magnetic resonance imaging
Sponsors
University Hospital, Bonn
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* liver cirrhosis with evaluation of TIPS implantation * patients who are 18 years of age or older
Exclusion criteria
* underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes known underlying disease witt potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy). * patients with contraindication for contrast-enhanced MRI * pregnant and breastfeeding women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial T1 relaxation time | Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. | T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\]. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial T2 relaxation time | Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. | T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\]. |
| Myocardial ECV | Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. | Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\]. |
Countries
Germany
Outcome results
None listed