Depression
Conditions
Keywords
Suicide, Suicidal Ideation, Suicidal Depression
Brief summary
Antidepressants are widely used to prevent suicidal risk. However, even though the use of antidepressants has been associated with a 40-60% decrease in suicidal risk, they do not seem to be sufficient and appropriate. Indeed recent studies have shown that patients with a history of suicide attempt and/or with current suicidal ideation (SI) respond less well to antidepressant treatments. This suggests that patients with depression with SI may be different from those with depression without SI, thus requiring specific treatments for both SI reduction and depressive remission. In other words, suicidal depression may be a specific subtype of depression. The study aims to characterize the clinical phenotype of patients with suicidal depression vs. those without suicidal depression, and to assess the occurrence of suicidal events at one year in patients with suicidal depression vs. without suicidal depression. All data having already been collected during the particpation of patients in various clinical research studies of the department
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Over 18 years old * Hospitalization in the Department of Emergency Psychiatry and Acute Care (Montpellier University Hospital) between 2012 and 2019 * Having being enrolled in one the department's clinical studies between 2012 and 2019 * Moderate to severe characterized depressive episode according to DSM-5 diagnostic criteria (severity assessed with BDI, IDSC-30 and QIDS)
Exclusion criteria
* Protection by law (guardianship or curatorship) * Deprivation of liberty (by judicial or administrative decision) * Bipolar disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| characterization of the patient clinical phenotype | day 1 | characterization of the patient clinical phenotype |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Suicidal events at one year | 1 year | Occurrence of suicidal events (actual, interrupted and aborted or self-aborted suicide attempts) assessed with C-SSRS suicidal behaviour subscale (4 yes/no questions) |
| Hospitalization for suicidal ideation | 1 year | Occurrence of hospitalization for suicidal ideation, based on the patient medical record |
Countries
France
Outcome results
None listed