Systemic Lupus Erythematosus
Conditions
Brief summary
Many laboratory markers can be measured for assessment of Lupus activity as aberrant manufacturing and imbalance of the cytokines of T-helper cell which already have been implicated within autoimmunity pathogenesis as IL-18 and IL-10 levels are usually elevated in lupus sufferers and correlated with SLEDAI score IL-17 has been linked to immune-mediated organ damage in several autoimmune diseases and recently it has been linked to pathogenesis of a murine model of lupus and human lupus Diverse cytokine abnormalities which common in lupus patients may skew T cells differentiation into IL-17-producing CD4+ and double negative T cells. This could promote the autoimmune process by activation of immune cells &stimulation of proliferation of B-cell and production of antibody
Interventions
DIAGNOSTIC_TESTSerum level of IL-17
Measurement of serum level of IL-17 : 1. To explore the role of IL-17 in systemic lupus erythematosus 2. To determine the relation between IL-17 and lupus disease activity 3. To analyze the correlation between IL-17 and internal organ affection (lupus nephritis , interstitial lung disease)
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* SLE will be diagnosed according to the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for SLE * Age ≥ 18 years. * Patients who are able and willing to give written informed consent
Exclusion criteria
-Any other autoimmune disease rather than SLE. - * Systemic diseases * Malignancy * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SLE disease activity index (SLEDAI) | 18 Months | • Assessment of the disease activity in the patients will be done by using the SLE disease activity index (SLEDAI). It potentially measures reversible manifestations of the underlying inflammatory disease process. The scale includes24 weighted attribute grouped into 9 domains. The final score is the sum of all attributed scores. * No activity 0 * mild activity: 1-5 * moderate activity: 6- 1 0 * high activity : 1 1 - 1 9 * very high \> 20 |
Countries
Egypt
Contacts
Primary ContactAya M Ahmed, assistant lecturer
Backup ContactFaten E Mohamed, professor
Outcome results
None listed