Bowel; Perforation, Fetus or Newborn, Hirschsprung Disease
Conditions
Brief summary
Hirschsprung's disease (HSCR) is a common digestive malformation with radiographic evidence of distal bowel obstruction and clinical signs of abdominal distension, vomiting, constipation, and failure to pass meconium. Bowel perforation (perforated HSCR) is a very serious complication of HSCR, but if this occurs it is most often in the neonatal period. The current study collected information on all cases diagnosed with perforated HSCR from multi-centers in China over 10 years, the aim was to evaluate the clinical features of perforated HSCR, and investigate possible risk factors for perforated HSCR in neonates.
Interventions
PROCEDUREEmergency surgical enterostomy
Emergency surgical enterostomy
Sponsors
Wuhan Children's Hospital
The First Affiliated Hospital of Zhengzhou University
Tongji Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Days to 30 Days
Healthy volunteers
No
Inclusion criteria
* Neonates (≤1 month age) * Diagnosed with HSCR * Suffered with bowel perforation
Exclusion criteria
* Patients complicated with suspected necrotizing enterocolitis (NEC), imperforate anus (IA), intestinal atresia, and meconium plug syndrome * Neonates who transferred from outside participating hospitals.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of bowel perforation in neonatal Hirschsprung disease (perforated HSCR) | 14 years | Cases with bowel perforation in neonatal Hirschsprung disease/ total neonatal Hirschsprung disease |
Outcome results
None listed