Candidiasis, Vaginal Infection
Conditions
Brief summary
The low Histatine-5 (HST-5) level of the saliva can lead to vaginal candidiasis. Because HST-5 level in the saliva can effect vaginal Ph, flora and local defence mechanisms. Histatine-5 is secreted in the parotis and submandibular glands. İt riches histidine amino ascid and have antifungal activity. Salivary proteins and their plasma levels were found as similar in the literature.
Detailed description
Women with regularly menstrual cycle will enroll in the study than will separate two groups: Study group: women with vaginal candidiasis ( diagnosed by clinic and lab.) Control group: women ( not have any vaginal infections candida and others) Saliva samples will be taken from two groups than HST-5 level will be analyzed. Finally HST-5 levels of the two groups will be compared . Women with diabetes, immun deficiency, pregnancy, virgin, menopausal period , premature ovarian failure will be excluded.
Interventions
OTHERsalivary sample
salivary sample
Sponsors
Usak State Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
women with regularly menstrual cycle , diagnosed candidal vaginosis and not have any vaginal infection. \-
Exclusion criteria
diabetes, immun deficiency, menopause, premature ovarian failure, pregnancy, virgin \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS | 1 month | we done salivary protein electrophoresis( as a small sample group ; consist of vaginal candidiasis and control patients) and Hst5 protein band was seen |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| SALIVARY HISTATINE-5 LEVEL IN THE WOMEN WITH VAGINAL CANDIDIASIS | 2 month | We found , low salivary Hst5 levels in women with vaginal candidiasis than control group (p=0.001) |
Countries
Turkey (Türkiye)
Outcome results
None listed