Aggressive Periodontitis, L-PRF, Photodynamic Therapy
Conditions
Brief summary
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.
Interventions
PROCEDUREL-PRF with antimicrobial photodynamic therapy
Application of L-PRF with antimicrobial photodynamic therapy in the defect
PROCEDUREantimicrobial photodynamic therapy without L-PRF
application of antimicrobial photodynamic therapy without L-PRF in the defect
Sponsors
Kafrelsheikh University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* systemically healthy * non- smoker, * not received any periodontal treatment within the last 6 months, * no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months
Exclusion criteria
* any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment, * any medical condition that required antibiotic prophylaxis before the treatment, * smoking, * pregnancy and lactation, * ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period, * any physical limitations or restrictions that might preclude normal oral hygiene procedures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical evaluation and measurements of the defect in millimeters | 9 months | Changes in clinical measurements in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF |
| Radiographic evaluation and measurements of the defect in millimeters | 9 months | Changes in bone formation in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF |
Countries
Egypt
Contacts
Primary ContactDalia R Issa, PhD
Outcome results
None listed