Early Identification and Predictive Parsing for High Risk Group of Schizophrenia

Early Identification and Predictive Parsing for High Risk Group of Schizophr

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05042739

Enrollment

189

Registered

2021-09-13

Start date

2017-05-01

Completion date

2021-04-01

Last updated

2021-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Risk Group of Schizophrenia

Keywords

Psychosis; UHR; CAARMS;SIPS; BSABS

Brief summary

An accurate identification of individuals at ultra-high risk (UHR) based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention. The diagnostic comparability of several psychometric tools is unknown. To address the psychometric comparability of the CAARMS, SIPS and BSABS for subjects who are the immediate family and three-generation blood kinship of patients with schizophrenia. To verify the viability and reliability of the three instruments for these subjects. subjects who all are immediate family and three-generation blood kinship of patients with schizophreniawere interviewed. All the subjects were assessed for a UHR state by three psychometric tools including CAARMS, SIPS and BSABS. The psychometric diagnosis results including at risk of psychosis (UHR+), not at risk of psychosis (UHR-), and Psychosis. Demographic and clinical characteristics interviewed by these three instruments were also measured. The inter-rater agreement was assessed for evaluation of the coherence of the three scales. Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years were also recorded.There is good diagnostic agreement between the CAARMS, SIPS and BSABS towards identification of UHR subjects who are immediate family and three-generation blood kinship of patients with schizophrenia. Also, these three instruments are reliable and valid for assessing and detecting at risk mental states in these subjects.

Interventions

DIAGNOSTIC_TESTCAARMS;SIPS; BSABS;

Comprehensive Assessment of At Risk Mental State (CAARMS); Structured Interview for Psychosis-Risk Syndrome (SIPS); Bonn Scale for the Assessment of Basic Symptoms (BSABS);

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* all are immediate family and three-generation blood kinship of patients with schizophrenia

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
The overall agreement percent	2 years	diagnostic comparison of CAARMS and SIPS, SIPS and BSABS, CAARMS and BSABS.
the inter-rater reliability	2 years	Inter-rater correlation (ICC) coefficients of CAARMS, SIPS and BSABS subscales.
the transition rates of UHR+ to psychosis within 2 years	2 years	Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years follow-up.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026