Breastmilk
Conditions
Keywords
Exercise
Brief summary
The investigators will determine the acute effect of exercise on breastmilk composition. Participants will come in to the lab on three different days, out of which they will exercise on two of these days and rest in the lab on the third day. The conditions will be randomly allocated to each participant. Breastmilk samples will be obtained in the morning of each test day, as well as immediately after, one hour after and four hours after the exercise/rest condition. Dietary intake will be standardized on the test days. At the time of study commencement, the trial (including planned analyses) is not fully funded. Additional milk will be stored for future analyses (not yet specified) when funding is secured.
Interventions
BEHAVIORALHigh intensity interval training
Four times four minutes treadmill interval training
BEHAVIORALModerate intensity training
Moderate intensity treadmill training
BEHAVIORALResting
No training
Sponsors
St. Olavs Hospital
Norwegian University of Science and Technology
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 6 to 12 weeks postpartum * Exclusive breastfeeding * Term birth
Exclusion criteria
* Known cardiovascular disease * Type 1 or 2 diabetes mellitus * Limited ability to exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Breastmilk metabolite composition | Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours) | Metabolomics profiling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adiponectin | Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours) | Concentration in breastmilk |
| Leptin | Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours) | Concentration in breastmilk |
| Insulin | Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours) | Concentration in breastmilk |
| Insulin Growth Factor-1 | Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours) | Concentration in breastmilk |
| Cytokine profiling (Multiplex 27) | Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours) | Concentration in breastmilk |
Other
| Measure | Time frame | Description |
|---|---|---|
| Body mass in kg | At baseline | Impedance scale |
| Height in metres | At baseline | stadiometer |
| Fat mass in kg | At baseline | Impedance scale |
| Muscle mass in kg | At baseline | Impedance scale |
| Cardiorespiratory fitness | At baseline | Peak oxygen uptake |
Countries
Norway
Outcome results
None listed