Aging, Inflammatory Response
Conditions
Brief summary
Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected. The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.
Interventions
OTHERResistance exercise
4 total resistance exercises that target all major muscle groups.
Sponsors
National Taiwan Normal University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: 20-80 * Healthy male * Without experience of resistance training
Exclusion criteria
* No acute or chronic musculoskeletal symptoms * Smoking * Alcohol or drug abuse * Fail to conduct resistance exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in biomarkers of inflammation | 24-hour during each study intervention | Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in metabolic parameters | 24-hour during each study intervention | Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL. |
| Changes in biomarkers of muscle damage | 24-hour during each study intervention | Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L. |
| Changes in glucose | 24-hour during each study intervention | glucose in mg/dL |
| Changes in complete blood count (CBC) | 24-hour during each study intervention | The white blood cell count and the count of each white blood cell type will be measured. |
| Borgs Ratings of Perceived Exertion (RPE) | 1-hour during each exercise intervention | Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion). |
| Changes in molecular markers in peripheral blood mononuclear cells (PBMC) | 24-hour during each study intervention | Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units. |
Countries
Taiwan
Outcome results
None listed