Epilepsy, Cardiomyopathies
Conditions
Brief summary
The aim of the study is to use multiparametric cardiac MRI to identify any abnormalities in myocardial structure and function in patients with epilepsy. A two-stage study design is planned as part of the study: 1. In the acute setting, cardiac MRI will be performed in patients before and after a tonic-clonic seizure and compared intraindividually. In this study arm, potential acute seizure-induced myocardial damage will be detected. 2. In the chronic setting, cardiac MRI will be performed in patients with known chronic epilepsy during the seizure-free interval to detect potential chronic myocardial damage (myocardial fibrosis) and compared with a control population. Within the group of epilepsy patients, possible associations with various epilepsy-specific characteristics (e.g., form, cause, onset, duration, and severity of epilepsy) will be investigated.
Interventions
DIAGNOSTIC_TESTCardiac magnetic resonance scan
Multiparametric cardiac magnetic resonance including traditional and quantitative functional and structural parameters
Sponsors
University Hospital, Bonn
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Inclusion criteria
1. diagnosed epilepsy 2. examination under usual antiepileptic pharmacotherapy or medication up-dosing (if medication was reduced during video-EEG recording) 3. age between 18-60 years
Exclusion criteria
1. underlying cardiac disease, e.g. coronary artery disease, previous myocardial infarction, previous myocarditis, complex congenital heart defect, known cardiomyopathy of other cause 2. pregnant and breastfeeding women 3. patients who use IUD for contraception 4. patients with a contraindication to contrast enhanced MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| T1 relaxation time | Measurement will be performed within 2 weeks after MRI scan. | T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\]. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| T2 relaxation time | Measurement will be performed within 2 weeks after MRI scan. | T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\]. |
| Extracellular volume fraction | Measurement will be performed within 2 weeks after MRI scan. | Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\]. |
| Myocardial strain | Measurement will be performed within 2 weeks after MRI scan. | Cardiac magnetic resonance feature-tracking will be used to asses left ventricular longitudinal, circumferential and radial strain (Strain values are given in \[%\]). |
Countries
Germany
Contacts
Primary ContactJulian A. Luetkens, PD Dr.
Backup ContactAlexander Isaak, Dr.
Outcome results
None listed