Pertussis (Whooping Cough)
Conditions
Brief summary
The purpose of this study is to determine the effectiveness of Adacel against pertussis disease in infants \< 2 months when administered during pregnancy following the current Advisory Committee on Immunization Practices (ACIP) recommendations, i.e., from 27 to 36 weeks of gestation, and 14 days or more before delivery.
Detailed description
The original study included cases recorded from 01 January 2011 through 31 December 2014, based on retrospective case-control methodology.
Interventions
Not applicable / dataset analysis
Sponsors
Sanofi Pasteur, a Sanofi Company
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Days to 2 Months
Healthy volunteers
Yes
Inclusion criteria
Cases were included if they met the following inclusion criteria: * Reported pertussis disease in the referenced EIP surveillance database * Age greater than 2 days and younger than two months of age * Resided in the catchment area on date of onset of their cough * Born in a hospital in their state of residence * ≥ 37 weeks of gestation at birth * Not adopted, in foster care or living in a residential care facility * Completed maternal interview * Completed infant and maternal information Controls were included if they met the following inclusion criteria: * Age greater than 2 days and younger than 2 months of age on date of cough onset for the corresponding case infant * Resided in the catchment area on date of cough onset for the corresponding case infant * Born in a hospital in their state of residence * ≥ 37 weeks of gestation at birth * Not adopted, in foster care or living in a residential care facility * Maternal interview completed * Infant and maternal information complete
Exclusion criteria
Cases were excluded if they met any of the following
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of pertussis cases in infants less than 2 months and matched controls | During the data collection period (from 01 January 2011 to 31 December 2014) | Vaccine effectiveness at preventing pertussis in infants less than 2 months of age was estimated using conditional logistic regression. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of pertussis cases requiring hospitalization in infants less than 2 months and matched controls | During the data collection period (from 01 January 2011 to 31 December 2014) | Vaccine effectiveness at preventing pertussis requiring hospitalization was estimated using conditional logistic regression |
Countries
France
Outcome results
None listed