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Correlation Between Cardiac Markers and Severity of COVID-19

Correlation Between Cardiac Markers and Severity of COVID-19 in Egyptian Population

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05040750
Enrollment
207
Registered
2021-09-10
Start date
2021-09-01
Completion date
2023-07-30
Last updated
2024-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Event

Brief summary

By July 9, 2020, the global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection had resulted in over 11.8 million confirmed cases and over 545000 deaths. Patients with a history of cardiovascular disease are especially vulnerable and have a bad prognosis. According to the findings, cardiac injury manifested by cardiac biomarker elevation is detected in a significant number of COVID-19 patients and is linked to poor outcomes and mortality. However, it is unclear how effective cardiac biomarkers are in COVID-19 prognosis and how to use these indicators.

Detailed description

The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to \>11.8 million confirmed cases with \>545000 deaths worldwide by July 9, 2020 Patients with preexisting cardiovascular conditions are particularly at risk and have poor prognosis data suggest that cardiac injury, manifested by cardiac biomarker elevation, is detected in a sizable of COVID-19 patients and is associated with adverse outcomes and increased mortality. However, how useful cardiac biomarkers are in COVID-19 prognosis and how to utilize these markers have not been well defined The study will include all moderate to severe COVID 19 patients admitted to ICU. Both genders within the age group 18-60 years were included. The primary outcome is the relation between cardiac markers and mortality rate in critically ill COVID 19 patients The secondary outcome is the relationship between cardiac and inflammatory and coagulation markers

Interventions

observe the relation between cardiac markers and mortality rate in critically ill COVID 19 patients

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

* all moderate to severe COVID 19 patients who were admitted to ICU. * Both genders * age group 18-60 years

Exclusion criteria

* a refusal to participate in the study, * pregnant patients, * patients aged \<18 or \>60. years, * recent history of acute myocardial infarction (\< 1 month before admission).

Design outcomes

Primary

MeasureTime frameDescription
relation between cardiac markers and mortality rate in critically ill COVID 19 patients4 monthrelate cardiac biomarkers to mortality rate

Secondary

MeasureTime frameDescription
relation ship between cardiac and inflammatory and coagulation markers4 monthcompare cardiac markers to inflammatory and coagulation laboratory findings

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026