Releasing of Inflammatory Mediators During Retreatment of Root Canals

The Effect of Different File Systems Used in Retreatment on the Release of Inflammatory Mediators

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05039502

Enrollment

Registered

2021-09-09

Start date

2020-10-01

Completion date

2021-06-01

Last updated

2021-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Response, Root Canal Infection

Brief summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Detailed description

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Interventions

OTHERProtaper Universal Retreatment

D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor

OTHERReciproc

R25 retratment files were used with X-Smart endomotor in reciprocal motion

OTHERXP-Endo finisher R

XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 68 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion criteria

* Patients who are immunocompromised * Patients under antibiotic or analgesic medication

Design outcomes

Primary

Measure	Time frame	Description
change of inflammatory mediator level	24 hours	The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026