Quality of Life and Patient Needs in Advanced High Grade Gliomas

Quality of Life and Patient Needs in Advanced High Grade Gliomas - A Prospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05039346

Enrollment

Registered

2021-09-09

Start date

2012-02-11

Completion date

2023-01-30

Last updated

2023-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaplastic Astrocytoma, Brain Tumor, Glioblastoma, Glioma, Quality of Life

Brief summary

There is limited knowledge regarding the quality of life and needs of patients with advanced high grade gliomas, especially during the end of life. By doing this research, we are able to assess caregiver and patient symptoms and needs during the end of life phase of patients with brain tumors.

Detailed description

Purpose: This is a pilot study to prospectively assess the symptoms and quality of life of patients and with advanced high grade glioma and their care takers. Specific Aims: The aim of this study is to investigate the symptoms of patients with advanced high grade glioma. Patients who failed 3rd line chemotherapy and who require at least occasional assistance will be prospectively followed and their symptoms will be prospectively assessed. Patient's caregiver will be interviewed following the death of the patient to assess clinical symptoms in the last weeks of life and around the time of death. Methods: Patients will undergo clinical symptom assessment via questionnaire. Patients will be followed by regular semi-structured phone interviews. Should a patient pass, four weeks following this, the patient's care giver will be interviewed.

Interventions

OTHERPhone interviews

Phone interviews will be used to determine the patient's quality of life, symptoms and performance status

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>18 * Tissue proven diagnosis of a high grade brain tumor * Disease progression by MRI * Therapy resistant tumor to 2nd line chemotherapy * Karnofsky Performance Scale (KPS) score of 60 or less * Patient will need to assign caregiver

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Quality of life and end of life symptoms in brain tumor patients	12 months	Assessment will be performed with validated questionnaire (MDASI-BT)
Examination	12 months	Clinical assessment

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026