Cow Milk Allergy
Conditions
Keywords
Cow milk allergy, Elimination diet, Anthropometry, Growth status
Brief summary
This study aimed to survey the growth of children who were on elimination diet due to cow milk allergy in Turkey. 0-5 year aged children diagnosed with cow's milk allergy (CMA) and healthy age-sex-matched children as the control group was planned for inclusion. Participants will be included in the study by consecutive sampling. The anthropometry measurements (height-for-age \[HFA\], weight-for-age \[WFA\], and weight-for-height \[WtHt\]) will be evaluated according to the Z-score using the WHO ANTHRO \[Z-score = Patient's value - Average value / Standard Deviation (SD)\]. The Z-score (SDS) in the average child by age was 0.
Detailed description
0-5 year aged children diagnosed with cow's milk allergy (CMA) and healthy age-sex-matched children as the control group was planned for inclusion. The study will constitute of two groups; group 1; the children who received cow's milk elimination (CME) diet and group 2; the healthy controls. Group 1 will constitute of children aged 0-5 years who received a CME diet due to CMA (Ig E-mediated and/or non-Ig E-mediated and/or mixed type)\], confirmed by an oral food challenge test (OFC) and had reintroduced cow's milk for at least ≥ three months ago. Participants will be included in the study by consecutive sampling. The anthropometric measurements (height-for-age \[HFA\], weight-for-age \[WFA\], and weight-for-height \[WtHt\]) will be evaluated according to the Z-score using the WHO ANTHRO \[Z-score = Patient's value - Average value / Standard Deviation (SD)\]. The Z-score (SDS) in the average child by age was 0.
Interventions
None listed
Sponsors
Saglik Bilimleri Universitesi
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
1 Months to 5 Years
Healthy volunteers
Yes
Inclusion criteria
Study Group Inclusion Criteria: * had a diagnosis of CMA by OFC, except children with known anaphylaxis * those on a CME diet or a specialized infant formula for at least three months * had reintroduced cow's milk for at least three months ago. * Children who excluded other foods in addition to cows' milk in the first four years of life for ≥ three months and who currently introduced these foods for at least ≥ three months were also enrolled in the CME group. Healthy group inclusion criteria: * did not have CMA and other allergic diseases * who had never been on a diet throughout their lives.
Exclusion criteria
* Known acute (e.g., influenza) or chronic (e.g., diabetes, immune deficiencies ) diseases, * history of systemic steroid use \> 0.5 mg/kg for more than one week in their life, * recurrent infections within the last three months, * food restriction other than food allergy (e.g., vegan, vegetarian), * moderate to severe asthma, and other medical or surgical conditions which might affect nutrition and growth.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body weight in kilograms-T0 | One month prior to the diagnosis of CMA | Body weight (kg) |
| Body weight in kilograms-T1 | On the 3-month of CME diet | Body weight (kg) |
| Body weight in kilograms-T2 | Three months after the end of the CME diet | Body weight (kg) |
| Body weight in kilograms-T3 | The last examination date of the patient after 3rd month control after CME diet | Body weight (kg) |
| Height in centimeters-T0 | One month prior to the diagnosis of CMA | Height (cm) |
| Height in centimeters-T1 | On the 3-month of CME diet | Height (cm) |
| Height in centimeters-T2 | Three months after the end of the CME diet | Height (cm) |
| Height in centimeters-T3 | The last examination date of the patient after 3rd month control after CME diet | Height (cm) |
| Head circumference in centimeters-T0 | One month prior to the diagnosis of CMA | Head circumference (cm) |
| Head circumference in centimeters-T1 | On the 3-month of CME diet | Head circumference (cm) |
| Head circumference in centimeters-T2 | Three months after the end of the CME diet | Head circumference (cm) |
| Head circumference in centimeters-T3 | The last examination date of the patient after 3rd month control after CME diet | Head circumference (cm) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood measurements-iron | The last examination date of the patient after 3rd month control after CME diet | Iron |
| Blood measurements-Folate | The last examination date of the patient after 3rd month control after CME diet | Folate |
| Blood measurements-Vitamin B12 | The last examination date of the patient after 3rd month control after CME diet | Vitamin B12 |
| Blood measurements-selenium | The last examination date of the patient after 3rd month control after CME diet | Selenium |
| Blood measurements-zinc | The last examination date of the patient after 3rd month control after CME diet | Zinc |
| Blood measurements-25-OH vitamin D | The last examination date of the patient after 3rd month control after CME diet | 25-OH vitamin D |
| Dietary intake | The last examination date of the patient after 3rd month control after CME diet | Three day dietary record |
| Blood measurements-Hemoglobin | The last examination date of the patient after 3rd month control after CME diet | Hemoglobin g/dl |
| Blood measurements-Sodium | The last examination date of the patient after 3rd month control after CME diet | sodium mg/ml |
| Blood measurements-Potassium | The last examination date of the patient after 3rd month control after CME diet | Potassium |
| Blood measurements-Albumin | The last examination date of the patient after 3rd month control after CME diet | Albumin |
| Blood measurements-Protein | The last examination date of the patient after 3rd month control after CME diet | Protein |
| Blood measurements-Calcium | The last examination date of the patient after 3rd month control after CME diet | Calcium |
Countries
Turkey (Türkiye)
Contacts
Primary ContactNazlı Ercan, MD
Outcome results
None listed