Hemorrhoids, Anal Fissure, Anal Fistula
Conditions
Brief summary
While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results. No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.
Interventions
Topical application of metronidazole cream on the anal verge every 8 hours after surgery
Patients received oral metronidazole 500 mg tablets every 8 hours after surgery
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients of either sex aged below 70 years * Underwent surgery for hemorrhoids, anal fissure, or simple anal fistula.
Exclusion criteria
* Grade I-II hemorrhoids. * acute anal fissure. * complex anal fistula * perianal abscess * perianal Crohn's disease * malignancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain score | at one day after surgery | Pain was assessed using visual analogue scale form 0 to 10, higher score indicates worse pain |
Countries
Egypt
Outcome results
None listed