MRI, Physiological Measurement, Sequence Optimization
Conditions
Brief summary
IRMaGe is a Joint Service Unit (UMS) which provides users of brain exploration equipment (clinical MRI and preclinical, TMS, EEG, NIRS and metabolomics). The methods available on this equipment are intended to evolve according to the most recent discoveries and this protocol aims to frame the developments necessary around clinical MRI for IRMaGe can continue to offer tools at the cutting edge of technology.
Detailed description
The studies will be carried out on healthy subjects and voluntary patients, who will have given their consent. Their main objective will be the development and optimization of sequence parameters or design stimulation paradigms in order to optimize the quality and relevance of the images produced taking into account the parameters anatomical, functional or metabolic while respecting the experimental constraints imposed by the protocol concerned (equipment of experimentation, additional physiological measurements, etc.). The main judgement criteria will be measurements inherent in the MRI sequence and a physiological measurement associated in the protocol concerned
Interventions
DEVICEMRI Protocol
Eye-tracker Eyelink (eye movements) BIOPAC : (electrodermal resistance) INVIVO Precess : breathing, arterial pressure, pulse, * NIRS Oxymon artinis medical system * tES (transcranial electrical stimulation, Neuroelectrics)
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Exploratory individual statistical analyzes on MRI data functional. No group analysis possible on these updates of MRI protocols
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants with normal or corrected vision * Participants affiliated to a social security scheme or beneficiaries of such a scheme * Participants with French as their mother tongue * Participants who have given the signed informed consent before carrying out any procedure related to the study. * Volunteer patients will be recruited as part of their follow-up at the CHU. Their pathology will be in agreement with that of the research protocol to be optimized.
Exclusion criteria
Criteria relating to contraindications to the explorations provided for by the MRI protocol: * metallic glitter in the eyes * retinal operation * claustrophobia * wearer of pacemaker or cardiac defribrillator or vascular clip or prosthesis cardiac or insulin pump or implanted device to deliver medication or hearing implant or prosthesis or vascular shunt or paragraph or screws, plate metal or tattoo or piercing or implanted metal object or lead shot hunt * Alcohol ingestion before the examination * Pregnant, lactating and parturient women * Major protected by law * Participants under administrative or judicial supervision * Participation in another ongoing study if the study may interfere with participation in the protocol MAP-IRMaGe.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diffusion Tensor Imaging Images | 1 to 3 hours | DTi sequences on IRM Achieva 3.0T dStream Philips |
| BOLD Signal | 1 to 3 Hours | EPI sequences during cognitive protocol on IRM Achieva 3.0T dStream Philips |
| Anatomical Images | 1 to 3 hours | Anatomical MR sequences on IRM Achieva 3.0T dStream Philips |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Near-infrared spectroscopy (NIRS) : Hb OHb concentration measurement | During MRI session | Acquired with NIRS Oxymon artinis medical system |
| Eye movements | During MRI session | Acquired by using eye-tracker (Eye-tracker Eyelink) breathing arteries pressure electrodermal conductance |
| tES | During MRI session | Transcranial Electrical stimulation, Neuroelectrics |
| Electrodermal resistance | During MRI session | Acquired on BIOPAC device allowing physiological measurements |
| Blood Pressure/pulse/Breathing | During MRI session | Acquired on INVIVO Precess |
Countries
France
Contacts
Primary ContactATTYE ARNAUD, MD, PhD
Backup ContactCOUSIN EMILIE, PhD
Outcome results
None listed