AKI
Conditions
Keywords
CRRT, ECMO, integration, circuit, combination
Brief summary
This study aimed to compare circuit lifespan of CRRT between Integration and Separation techniques during ECMO support.
Interventions
DEVICECombination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
ECMO patients \>18 years old who met the KDIGO criteria for acute kidney injury and required continuous renal replacement therapy (CRRT). Inclusion criteria were as follows: 1. Refractory acidosis, defined as pH \< 7.2 or serum bicarbonate (HCO₃-) \< 15 mmol/L 2. Refractory volume overload 3. Refractory hyperkalemia, defined as serum potassium (K⁺) \> 6.2 mEq/L or presence of electrocardiographic changes 4. Anuria or oliguria, defined as urine output \< 0.5 mL/kg/hr for 6-12 hours 5. Elevated BUN \>100 mg/dL or presence of uremic symptoms Increased intracranial pressure
Exclusion criteria
1. Pregnancy 2. Heparin contraindication 3. Chronic kidney disease with CRRT 4. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CRRT Circuit lifespan | 72 hours, extended maximum to 120 hours | The time until a CVVHDF malfunction was identified |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serious Adverse Events | [Time Frame: 72 hours, extended maximum to 120 hours of filter lifespan] | Bleeding at exit site, systemic bleeding, need for blood transfusion, air embolism, positive-blood culture infection, hemolysis |
| 28-day mortality | 28-day after randomization | 28-day mortality, status yes or no |
| Pressure at various points of CRRT circuit | [Time Frame: 72 hours, extended maximum to 120 hours of filter lifespan] | Pressure point at CRRT circuit; access pressure, return pressure, filter pressure, Pressure drop, and Transmembrane pressure |
Countries
Thailand
Outcome results
None listed